HCTZIDE 12.5 mg Tablets combine hydrochlorothiazide and triamterene to manage hypertension (high blood pressure) and edema (fluid retention) effectively. Hydrochlorothiazide works by increasing urine output, thus reducing excess fluid and lowering blood pressure. Triamterene helps maintain potassium levels in the body, preventing electrolyte imbalances. Together, they provide a synergistic effect, promoting optimal cardiovascular health.